Background: Chronic pain of peripheral nerve origin is a prevalent condition that often remains resistant to conservative therapies. Peripheral nerve stimulation (PNS) has proven to be an effective intervention for managing this type of pain. Receiver based PNS is a neuromodulation therapy designed to alleviate chronic pain by targeting specific peripheral nerves. This system involves implanting an electrode array and separate receiver to target pain-causing nerves, offering relief for patients with persistent pain.

Case Report: A case series involving 9 patients with chronic peripheral nerve pain treated with a peripheral nerve stimulation system with a separate receiver is presented. These patients had pain localized to specific nerve targets, including the suprascapular, infrapatellar saphenous, and superior cluneal nerves. After successful trials, the Freedom® PNS System (Curonix LLC) was implanted permanently. Pain relief was assessed using the Verbal Rating Scale (VRS), showing significant improvement in pain scores from baseline to follow-up periods of one, 3, and 6 months.

Conclusion: PNS is a safe, effective method for treating chronic pain that originates in the peripheral nerves and is resistant to conservative therapy.

KEYWORDS: Chronic pain, case series, infrapatellar saphenous (IPS) nerve, lumbar medial branches, peripheral nerve stimulation, superior cluneal nerves