BACKGROUND: Idiopathic trigeminal neuralgia (ITN) affects approximately 0.16% to 0.3% of the population, with severe complications occurring in 15% of cases. Existing treatments often yield suboptimal outcomes.

CASE REPORT: This study evaluates the clinical efficacy of Gasserian ganglion stimulation (GGS) for ITN management in 2 patients. GGS led to significant symptom improvement in both patients, with one patient achieving complete remission. Compared to conventional therapies, GGS demonstrated a 30% higher efficacy rate, suggesting its potential as a superior therapeutic option. However, limitations include the small sample size and the mandibular nerve branch restriction.

CONCLUSIONS: Despite the constraints, our findings are noteworthy, as previous GGS research has primarily focused on treatment failure or nerve damage. Our study suggests GGS could transform ITN management by providing a more effective and less invasive treatment alternative.

KEYWORDS: Gasserian ganglion stimulation, Idiopathic trigeminal neuralgia, mandibular nerve, neuromodulation